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Prepare the Fried Chicken:
Marinate the chicken: Place the chicken pieces in a large bowl and pour over the buttermilk. Let it marinate for at least 30 minutes to overnight in the fridge for extra flavor.
Season the flour: In a shallow dish, mix the flour, garlic powder, onion powder, paprika, salt, pepper, and cayenne (if using).
Coat the chicken: After marinating, dredge each chicken piece in the seasoned flour mixture, ensuring it’s fully coated. Shake off any excess flour.
Fry the chicken: Heat the vegetable oil in a large skillet or deep fryer over medium-high heat. Carefully add the chicken pieces to the hot oil, cooking for 10-12 minutes per side or until golden brown and the internal temperature reaches 165°F (74°C). Remove the chicken and drain on paper towels.
Make the Mac and Cheese:
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